Distribution and Dynamics of Intracellular ATP Level, and their Regulation

• IMAMURA Hiromi

  The Hakubi Center for Advanced Research, Kyoto University

• ANDO Tomomi

  Department of Virology II, National Institute of Infectious Diseases

• FUJIKAWA Makoto

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

Bibliographic Information

Other Title

• 細胞内ATPの分布とダイナミクス，その制御
• サイボウ ナイ ATP ノ ブンプ ト ダイナミクス,ソノ セイギョ

Abstract

ATP is indispensable for all living organisms. Despite its importance, however, distribution and dynamics of ATP level inside living cells still remained unclear. We have developed FRET-based ATP biosensors, “ATeam” and “GO-ATeam”, which enabled us to visualize intracellular ATP level. Using these biosensors, we have successfully evaluated the effect of IF1 protein and Ca²⁺ on regulation of ATP level. Also, we found that replication of hepatitis C virus genome resulted in the declination of cytosolic ATP level of host cells and the formation of putative virus replication sites with high ATP levels.<br>

Journal

• Seibutsu Butsuri

  Seibutsu Butsuri 53 (1), 020-023, 2013

  The Biophysical Society of Japan General Incorporated Association

Keywords

• ATP
• calcium
• mitochondria
• F_oF₁
• IF1
• HCV

Details

• CRID: 1390001206534256256
• NII Article ID: 10031139021
• NII Book ID: AN00129693
• DOI: 10.2142/biophys.53.020
• COI: 1:CAS:528:DC%2BC3sXisVWntrg%3D
• ISSN: 13474219
• ISSN: 05824052
• NDL BIB ID: 024274464
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024274464
• Web Site: https://www.jstage.jst.go.jp/article/biophys/53/1/53_020/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013204384
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed