<i>In situ</i> Monitoring of Drug Action Using Sensors

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  • KATSU Takashi
    Faculty of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • KOMAGOE Keiko
    Faculty of Pharmaceutical Sciences, Okayama University
  • MASUDA Kazufumi
    Graduate School of Clinical Pharmacy, Shujitsu University School of Pharmacy, Shujitsu University
  • KATO Hisato
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University School of Pharmacy, Shujitsu University
  • INOUE Tsuyoshi
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Faculty of Pharmaceutical Sciences, Okayama University

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Other Title
  • センサーを用いる薬物作用の<i>in situ</i>モニタリング
  • センサー オ モチイル ヤクブツ サヨウ ノ in situ モニタリング

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Abstract

The application of electrochemical sensors to biochemical analysis is attractive, because the measurement is fast, easy, and continuous in a turbid cell suspension. In addition, the apparatus used is inexpensive. In this paper, we report on how electrochemical sensors, such as oxygen electrode and ion sensors, are useful to analyze the photoinactivation of bacteria induced by dyes. Furthermore, we coupled a K+ sensor with spectrometry. This methodology enabled us to rapidly screen the sizes of pores formed in a liposomal membrane. We also describe a simple method for constructing ion sensors in a laboratory.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 62 (2), 121-130, 2013

    The Japan Society for Analytical Chemistry

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