SLIT Improves Cedar Pollinosis by Restoring IL-10 Production from Tr1 and Monocytes : IL-10 Productivity Is Critical for Becoming Allergic

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Author(s)

    • YUTA Atsushi
    • Department of Otorhinolaryngology, Mie University Graduate School of Medicine
    • KAKEDA Masato
    • Department of Dermatology, Mie University Graduate School of Medicine
    • OGIHARA Hitomi
    • Department of Otorhinolaryngology, Mie University Graduate School of Medicine
    • KUROKAWA Ichiro
    • Department of Dermatology, Mie University Graduate School of Medicine
    • TAKEUCHI Kazuhiko
    • Department of Otorhinolaryngology, Mie University Graduate School of Medicine

Abstract

<b>Background:</b> Allergen-specific immunotherapy (SIT) is currently used for several allergic disorders and IL-10-producing regulatory T cells (Tr1) induced by SIT suppress allergic reactions. We investigated the relation between IL-10 production and acquiring allergy.<br> <b>Methods:</b> A prospective study was undertaken to evaluate the effect of SIT on IL-10 production in T cells and other cell fractions in children with pollinosis. In addition, blood samples were collected from non-allergic healthy controls and patients with pollinosis to compare the levels of IL-10 production. PBMC were cultured with pollen peptides or control allergens, and the IL-10 production from monocyte and CD4 T cell was analyzed.<br> <b>Results:</b> Monocytes and CD4 T cells from SIT group of patients produced high levels of IL-10, suggesting that the induction of IL-10 is essential for inducing T cell tolerance. IL-10 production from monocytes and T cells was significantly increased in non-allergic controls compared to patients with pollinosis. This high IL-10 production was observed even when PBMC were stimulated with antigens other than pollen peptides.<br> <b>Conclusions:</b> IL-10 is critical for induction of specific T cell tolerance, and increased production of IL-10 by monocytes and T cells during inflammatory responses or after SIT may influence effector cells in allergy. Present data implicates that the low productivity of IL-10 by monocytes and T cells is closely related with sensitivity to multiple allergens, and resistance to allergic diseases. Augmentation of constitutive IL-10 production from immune system is a potential therapeutic approach for allergic disorders.<br>

Journal

  • Allergology International

    Allergology International 60(1), 45-51, 2011-03-01

    Japanese Society of Allergology

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