Fenugreek Attenuates Lipid Accumulation in Normal Rats

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  • Muraki Etsuko
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Matsuoka Chisato
    Hikone Central Hospital
  • Oikawa Rina
    Hashimoto Eye Clinic
  • Sato Shinobu
    World Intec Co., Ltd.
  • Chiba Hiroshige
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Tsunoda Nobuyo
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Kasono Keizo
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

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  • フェヌグリークは正常ラットの脂肪蓄積抑制に関与する
  • フェヌグリーク ワ セイジョウ ラット ノ シボウ チクセキ ヨクセイ ニ カンヨ スル

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Abstract

We investigated the preventive efficacy of dietary fenugreek (Trigonella foenum-graecum L.) on diet-induced metabolic disorder in normal SD rats. The diets employed were a standard diet (STD) and a high-fat high-sucrose (HFS) diet, both with or without fenugreek. Normal SD rats fed the HFS diet containing fenugreek showed a lower body weight gain, energy efficiency ratio and white adipose tissue weight than normal SD rats fed the STD diets. In the groups fed the fenugreek-containing diets, total cholesterol levels in the liver were lower, whereas excretion of total bile acids into the feces was increased. However, fenugreek had no significant effect on glucose tolerance. These results suggest that fenugreek inhibits body weight gain through an increase of lipid excretion into feces, and prevention of lipid accumulation in the liver and white adipose tissue in normal rats.

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