Association between Selenium Intake and Serum Selenium Levels in Dialysis Patients

• Takemasa Mutsuko

  Department of Clinical Nutrition Faculty of Health Science and Technology, Kawasaki University of Medical Welfare Department of Nutrition, Kawasaki Medical School Hospital

• Ichikawa Kazuko

  Department of Nutrition, Kawasaki Medical School Hospital

Bibliographic Information

Other Title

• 血液透析患者における血清セレン濃度とセレン摂取量
• ケツエキ トウセキ カンジャ ニ オケル ケッセイ セレン ノウド ト セレン セッシュリョウ

Abstract

Objective: Nutritional deficiency has long been an issue among hemodialysis (HD) patients. Low levels of serum selenium in particular, which are frequently observed in HD patients, are a risk factor for cardiovascular complications and infections, and are also associated with a high mortality rate. Here, we assessed the association between selenium intake and serum selenium levels in HD patients.<br>Method: Ten HD patients (4 men, 6 women) aged 62.7 ± 5.9 years were enrolled for this study. The mean duration of dialysis treatment was 190 ± 157 months. The patients' dietary selenium intake over 4 days, serum biochemistry profile, and physical conditions were assessed.<br>Results: Mean dietary selenium intake and serum selenium levels were 51.1 ± 14.3 (31.6~70.8) μg/day and 12.7 ± 2.4 (9.0~17.3) μg/dl, respectively. Serum selenium levels showed a significant positive correlation with serum urea nitrogen levels (r = 0.770), and protein (r = 0.697) and selenium (r = 0.673) intake. On the other hand, selenium intake showed a significant positive correlation with energy (r = 0.721), protein (r = 0.733), phosphorous (r = 0.662), and potassium (r = 0.669) intake. The correlation between serum selenium levels (μg/dl, Y) and protein intake per ideal body weight (g/kgIBW/day, X₁), selenium intake (μg/day, X₂), and potassium intake (mg/day, X₃) produced a regression line as follows: Y = 10.633X₁ + 0.142X₂ – 0.004X₃ + 3.509 (r = 0.962, p = 0.001).<br>Conclusion: These results indicate that reducing protein intake may lower selenium intake, leading to reduced levels of serum selenium.

Journal

• The Japanese Journal of Nutrition and Dietetics

  The Japanese Journal of Nutrition and Dietetics 70 (6), 325-330, 2012

  The Japanese Society of Nutrition and Dietetics

Keywords

• hemodialysis
• selenium intake
• serum selenium levels
• nutrition care

Details

• CRID: 1390282681526284032
• NII Article ID: 130004553493
• NII Article ID: 10031143680
• NII Book ID: AN00023058
• DOI: 10.5264/eiyogakuzashi.70.325
• COI: 1:CAS:528:DC%2BC3sXhs1Cqtr0%3D
• ISSN: 18837921
• ISSN: 00215147
• NDL BIB ID: 024189606
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024189606
• Web Site: https://search.jamas.or.jp/link/ui/2013130971
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed