超選択的動注化学放射線療法が有効であった上顎歯肉小細胞癌の1例

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  • A case of small cell neuroendocrine carcinoma arising in the maxillary gingiva treated effectively by high-dose intra-arterial cisplatin and concurrent radiation therapy
  • チョウセンタクテキドウ チュウ カガク ホウシャセン リョウホウ ガ ユウコウ デ アッタ ウワアゴ シニク ショウサイボウガン ノ 1レイ

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We describe a rare case of small cell neuroendocrine carcinoma （SNEC） arising in the maxillary gingiva that responded to high-dose intra-arterial cisplatin and concurrent radiation therapy （RADPLAT）. A 58-year-old man was referred to our clinic because of a swelling in the right maxillary gingiva. The clinical diagnosis was a malignant tumor of the upper gingiva and a biopsy was performed. The histopathological diagnosis was SNEC. Four courses of intra-arterial infusion of CDDP （50 mg） were administered into the maxillary artery via the femoral artery by the Seldinger method, with concurrent external radiation （50 Gy）. As complete response （CR） was obtained. The patient subsequently received ten courses of systemic adjuvant chemotherapy （CBDCA: 500 mg, VP-16: 180 mg） in the outpatient clinic. He has remained free of disease for 27 months after RADPLAT. However, a PET-CT scan showed multiple systemic metastases. We planned to give the patient systemic chemotherapy again, but his renal function and liver function worsened considerably. Finally, the patient died of multiple organ failure within the same month.

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