Potential Roles of GPI-Anchor Remodeling in Protein Trafficking and Raft Association in Mammalian Cells

• Fujita Morihisa

  Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan

Bibliographic Information

Other Title

• 哺乳動物GPI アンカーのリモデリング機構とタンパク質輸送・ラフト局在における役割

Abstract

Post-translational modification of proteins with glycosylphosphatidylinositol (GPI) is mediated by a mechanism that is conserved in all eukaryotes. GPI-anchored proteins are characterized by their association with specialized membrane domains called “lipid rafts,” and the GPI-anchors are thought to regulate their intracellular trafficking pathways. These characteristics are regulated by the structural properties of GPI-anchors, remodeling enzymes and recognition molecules. The biogenesis of GPI-anchored proteins occurs in the ER, following which they are transported to the plasma membrane via the Golgi apparatus. During transport, the structures of the GPI-anchors are remodeled. In this minireview, the structural remodeling of mammalian GPI-anchors and regulation of the transport and localization of GPI-anchored proteins are described.

Journal

• Trends in Glycoscience and Glycotechnology

  Trends in Glycoscience and Glycotechnology 24 (140), 244-257, 2012

  FCCA(Forum: Carbohydrates Coming of Age)

Keywords

• glycosylphosphatidylinositol
• endoplasmic reticulum
• Golgi apparatus
• lipid raft
• structural remodeling

Details

• CRID: 1390001204370737408
• NII Article ID: 10031146677
• NII Book ID: AA10995236
• DOI: 10.4052/tigg.24.244
• ISSN: 18832113
• ISSN: 09157352
• NDL BIB ID: 024179996
• Web Site: http://id.ndl.go.jp/bib/024179996
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024179996
• Web Site: https://search.jamas.or.jp/link/ui/2013148936
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed