Chemistry Based Approach for Degradation of Target-Oligosaccharides Using Photo-Activatable Organic Small Molecules

• Takahashi Daisuke

  Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

• Toshima Kazunobu

  Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

Bibliographic Information

Other Title

• 光感受性有機小分子により標的糖鎖を選択的に光分解する化学的新手法の開発

Abstract

Molecular design, chemical synthesis, and biological evaluation of several organic small molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically active oligosaccharides.

Journal

• Trends in Glycoscience and Glycotechnology

  Trends in Glycoscience and Glycotechnology 24 (140), 258-276, 2012

  FCCA(Forum: Carbohydrates Coming of Age)

Keywords

• photodegradation
• boronic acid
• anthraquinone
• fullerene
• hybrid molecule

Details

• CRID: 1390282679347447552
• NII Article ID: 10031146678
• NII Book ID: AA10995236
• DOI: 10.4052/tigg.24.258
• ISSN: 18832113
• ISSN: 09157352
• NDL BIB ID: 024180013
• Web Site: http://id.ndl.go.jp/bib/024180013
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024180013
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed