Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes
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- Takano Katsura
- Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan
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- Yamasaki Hiroshi
- Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan
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- Kawabe Kenji
- Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan
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- Moriyama Mitsuaki
- Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan
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- Nakamura Yoichi
- Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan
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Abstract
Depression is one of the most prevalent and livelihood-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood. Recent studies suggest that the neuronal plasticity involved with brain-derived neurotrophic factor (BDNF) plays an important role in the recovery from depression. Some antidepressants are reported to induce BDNF expression in vivo; however, the mechanisms have been considered solely in neurons and not fully elucidated. In the present study, we evaluated the effects of imipramine, a classic tricyclic antidepressant drug, on BDNF expression in cultured rat brain astrocytes. Imipramine dose-dependently increased BDNF mRNA expression in astrocytes. The imipramine-induced BDNF increase was suppressed with inhibitors for protein kinase A (PKA) or MEK/ERK. Moreover, imipramine exposure activated transcription factor cAMP response element binding protein (CREB) in a dose-dependent manner. These results suggested that imipramine induced BDNF expression through CREB activation via PKA and/or ERK pathways. Imipramine treatment in depression might exert antidepressant action through BDNF production from astrocytes, and glial BDNF expression might be a target of developing novel antidepressants.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 120 (3), 176-186, 2012
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205179037824
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- NII Article ID
- 10031147564
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- NII Book ID
- AA11806667
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- COI
- 1:STN:280:DC%2BC3s%2FmtVOgsg%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 024093768
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- PubMed
- 23076128
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed