Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

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  • Liu Lei
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China Laboratory of Molecular and Cellular Physiology, School of Life Sciences, Northeast Normal University, China
  • Li Bingjin
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China Jilin Key Laboratory of Animal Resource Conservation and Utilization, School of Life Sciences, Northeast Normal University, China
  • Zhou Yang
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Wang Liang
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Tang Fang
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Shao Dongyuan
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Jiang Xiulan
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Zhao Hui
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China
  • Cui Ranji
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China Jilin Key Laboratory of Animal Resource Conservation and Utilization, School of Life Sciences, Northeast Normal University, China
  • Li Yuxin
    Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China Laboratory of Molecular and Cellular Physiology, School of Life Sciences, Northeast Normal University, China

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Recent studies in vivo and vitro have shown that Fuzi polysaccharide has an antidepressant-like effect. Polysaccharide and total alkaloid are the two most important components of Fuzi. However, little is known about the antidepressant-like effect of Fuzi total alkaloid. To investigate the antidepressant-like effect of Fuzi total alkaloid, behavioral studies were performed in the open field test and forced swimming test. Repeated intragastric administration of Fuzi total alkaloid for 7 days (10 mg/kg) to normal mice decreased immobility time compared to the vehicle group. Furthermore, repeated administration of Fuzi total alkaloid (10 or 30 mg/kg) to ovariectomized mice also decreased immobility time in a dose-dependent manner. However, these antidepressant-like behavioral effects were not simply due to locomotor hyperactivity. Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice. These results indicate that the CREB-BDNF pathway may be involved in the antidepressant-like effect of Fuzi total alkaloid in ovariectomized mice.

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