Histopathological Changes in Joint Components in a Rat Knee Joint Contracture Model Following Mobilization

• Watanabe Masanori

  Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University Division of Health Sciences, Kanazawa University Graduate School of Medical Sciences

• Hoso Masahiro

  Division of Health Sciences, Kanazawa University Graduate School of Medical Sciences

• Kojima Satoshi

  Division of Health Sciences, Kanazawa University Graduate School of Medical Sciences Department of Medical Health Science, Kinjo University

• Matsuzaki Taro

  Division of Health Sciences, Kanazawa University Graduate School of Medical Sciences

• Hibino Itaru

  Department of Physical Therapy, Faculty of Rehabilitation Science, Nagoya Gakuin University

Abstract

[Purpose] The aim of this study was to investigate the histopathological effects of mobilization on joint components using a rat knee joint contracture model. [Method] Twenty-two male Wistar rats (aged 9 weeks) were randomly divided into an experimental group (n = 18) and a control group (n = 4). The experimental group had the right posterior limb knee joint immobilized for 8 weeks to induce contracture after which this group was subdivided into three subgroups–immobilized, treatment, and non-treatment groups. In the immobilized group (n = 6), knee joint specimens were collected immediately after immobilization. The non-treatment group (n = 6) was bred normally for 8 weeks, while the treatment group (n = 6) underwent mobilization during the same 8 weeks. After breeding, we prepared tissue specimens of the knee joint for observation in the sagittal plane and examined them using a light microscope. [Results] Compared to the non-treatment group, the treatment group showed an increase in the number of fat cells in the synovial subintima and a reduction in the density of collagen fiber bundles in the posterior joint capsule. [Conclusion] Joint mobilization appears to effectively improve joint function.

Journal

• Journal of Physical Therapy Science

  Journal of Physical Therapy Science 24 (11), 1199-1203, 2012

  The Society of Physical Therapy Science

Keywords

• Mobilization
• Contracture
• Histopathology

Details

• CRID: 1390282679305664384
• NII Article ID: 130004431817
• NII Article ID: 10031148269
• NII Book ID: AA10798949
• DOI: 10.1589/jpts.24.1199
• ISSN: 21875626
• ISSN: 09155287
• Web Site: https://www.jstage.jst.go.jp/article/jpts/24/11/24_1199/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013357979
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed