Molecular Mechanism of Synapse Formation by Synaptic Organizer

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  • UEMURA Takeshi
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo Present Address: Department of Molecular and Cellular Physiology, Shinshu University School of Medicine

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  • シナプスオーガナイザーによるシナプス形成の制御機構
  • シナプスオーガナイザー ニ ヨル シナプス ケイセイ ノ セイギョ キコウ

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Abstract

Formation of synaptic connections between nerve cells is the key to understanding neuronal development. Despite the wealth of in vitro information, fundamental questions regarding how synapses are formed in the mammalian brain remain unanswered. Glutamate receptor (GluR) δ2 selectively expressed in cerebellar Purkinje cells is essential for synaptic formation in vivo. We showed that the trans-synaptic interaction of postsynaptic GluR<surname>δ</surname>2 and presynaptic neurexins through secreted cerebellin precursor protein 1 (Cbln1) mediates cerebellar synapse formation. We also demonstrated that GluRδ2 triggers synapse formation by tetramerization of neurexins through Cbln1. These finding provide a molecular insight into the mechanism of synapse formation in the brain.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 53 (2), 090-093, 2013

    The Biophysical Society of Japan General Incorporated Association

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