Diamine Derivatives Accelerate Photochemical C→U Transition in DNA Double Strand

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Author(s)

    • FUJIMOTO Kenzo
    • School of Materials Science, Japan Advanced Institute of Science and Technology
    • FUTAMURA Daiki
    • School of Materials Science, Japan Advanced Institute of Science and Technology
    • SAKAMOTO Takashi
    • School of Materials Science, Japan Advanced Institute of Science and Technology

Abstract

For the improvement of the deamination reaction of cytosine in the photocrosslinked DNA double strand, the effect of additives on the deamination reaction was evaluated. The results indicated that diamine derivatives can accelerate the reaction in a concentration-dependent manner. This provides a new design of artificial oligonucleotides having higher photoediting activities.

Journal

  • Chemistry Letters

    Chemistry Letters 42(3), 289-291, 2013-03-05

    The Chemical Society of Japan

References:  21

Codes

  • NII Article ID (NAID)
    10031155783
  • NII NACSIS-CAT ID (NCID)
    AA00603318
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    03667022
  • Data Source
    CJP  J-STAGE 
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