X線溶液散乱と分子動力学シミュレーションで探るタンパク質の構造揺らぎ  [in Japanese] Protein Dynamics Investigated by Small-angle X-ray Scattering and Molecular Dynamics Simulations  [in Japanese]

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Author(s)

    • 池口 満徳 IKEGUCHI Mitsunori
    • 横浜市立大学大学院生命医科学研究生命医科学専攻 Graduate School of Medical Life Science, Yokohama City University
    • 佐藤 衛 SATO Mamoru
    • 横浜市立大学大学院生命医科学研究生命医科学専攻 Graduate School of Medical Life Science, Yokohama City University

Abstract

The combination of small-angle X-ray solution scattering (SAXS) experiments and molecular dynamics (MD) simulations is now becoming a powerful tool to study protein dynamics in solution at an atomic resolution. We have developed a method called MD-SAXS, in which this combination is used with explicit evaluation of X-ray scattering from water molecules hydrating protein molecules. This method offers a link between low-resolution structural information from SAXS and the three-dimensional high-resolution structure. The study using MD-SAXS method revealed the importance of intrinsic dynamics of DNA-binding protein EcoO109I in its function.

Journal

  • Nihon Kessho Gakkaishi

    Nihon Kessho Gakkaishi 55(1), 24-31, 2013-02-28

    The Crystallographic Society of Japan

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Codes

  • NII Article ID (NAID)
    10031156002
  • NII NACSIS-CAT ID (NCID)
    AN00188364
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    03694585
  • NDL Article ID
    024334913
  • NDL Call No.
    Z15-138
  • Data Source
    CJP  NDL  J-STAGE 
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