Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients
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- Ito Mitsuru
- Kuma Hospital, Kobe 650-0011, Japan
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- Kitanaka Akira
- Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun 761-0793, Japan
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- Arishima Takeshi
- Kuma Hospital, Kobe 650-0011, Japan
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- Kudo Takumi
- Kuma Hospital, Kobe 650-0011, Japan
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- Nishihara Eijun
- Kuma Hospital, Kobe 650-0011, Japan
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- Kubota Sumihisa
- Kuma Hospital, Kobe 650-0011, Japan
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- Amino Nobuyuki
- Kuma Hospital, Kobe 650-0011, Japan
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- Hiraiwa Tetsuya
- First Department of Medicine, Osaka Medical College, Takatsuki 569-8686, Japan
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- Hanafusa Toshiaki
- First Department of Medicine, Osaka Medical College, Takatsuki 569-8686, Japan
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- Miyauchi Akira
- Kuma Hospital, Kobe 650-0011, Japan
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Abstract
Apolipoprotein B-48 (ApoB-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis. We evaluated the effect of L-thyroxine (L-T4) replacement on serum ApoB-48 levels in patients with primary hypothyroidism. Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study. The lipid profiles, including ApoB-48, were measured in patients with hypothyroidism before and 3 months after L-T4 replacement. After L-T4 replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein(a) (Lp(a)), were significantly decreased in patients with OH. In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (ApoB), and ApoB-48 decreased significantly after L-T4 replacement. The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA-1), and Lp(a) did not change significantly. In all 36 patients, the reduction in the ApoB-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P<0.05). This study showed clearly that L-T4 replacement might reduce serum levels of ApoB-48 in both OH and SH patients. Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism.
Journal
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- Endocrine Journal
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Endocrine Journal 60 (1), 65-71, 2013
The Japan Endocrine Society
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Details 詳細情報について
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- CRID
- 1390001206298290304
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- NII Article ID
- 10031156724
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- NII Book ID
- AA10901436
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- COI
- 1:STN:280:DC%2BC38bnsl2htw%3D%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 22986485
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed