Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals — possible involvement of the insulin resistance

DOI Web Site PubMed 被引用文献10件 参考文献82件
  • Mizuno Yuji
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan
  • Harada Eisaku
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan
  • Katoh Daisuke
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
  • Kashiwagi Yusuke
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
  • Morikawa Yoshinobu
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan First Department of Internal Medicine, Nara Medical University, Nara 634-8521, Japan
  • Nakagawa Hitoshi
    First Department of Internal Medicine, Nara Medical University, Nara 634-8521, Japan Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan
  • Yoshimura Michihiro
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
  • Saito Yoshihiko
    First Department of Internal Medicine, Nara Medical University, Nara 634-8521, Japan
  • Yasue Hirofumi
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan

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  • Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -

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抄録

B-type natriuretic peptide (BNP) is produced by the heart and its plasma level is increased with the severity of left ventricular (LV) dysfunction/hypertrophy. The normal heart preferentially utilizes fatty acids as energy substrates. Plasma BNP levels are reported to be lower in obese individuals. We examined the relationship between BNP production and plasma free fatty acids (FFA), homeostasis model assessment of insulin resistance (HOMA-IR), and LV dysfunction/ hypertrophy. We examined the plasma BNP levels and FFA at the aortic root (AO) and coronary sinus (CS) as well as hemodynamic parameters in 62 patients (38 men and 24 women, 62.5±11.7 yrs) who underwent cardiac catheterization. Log BNP (AO) had a significant positive correlation with log BNP (CS-AO) (r=0.877, P<0.001). Log BNP(CS-AO) had a significant negative correlation with BMI (r=-0.558, P<0.001), waist circumference (WC) (r=-0.574, P<0.001), log FFA(AO) (r=-0.643, P<0.001), log triglyceride (r=-0.431, P<0.001), and log HOMA-IR (r=-0.463, P<0.001) and a significant positive correlation with left ventricular mass index (LVMI) (r=0.403, P=0.001). The multivariable regression analyses including log HOMA-IR, LVMI, and age as an independent variable revealed that HOMA-IR and LVMI were significant predictors of log BNP (CS-AO) or BNP production (P=0.001 and 0.004, respectively). We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 60 (1), 87-95, 2013

    一般社団法人 日本内分泌学会

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