Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

• Senmaru Takafumi

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Fukui Michiaki

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Kuroda Masaaki

  Department of Gastroenterology, Yamashiro Public Hospital, Kizugawa 619-0214, Japan

• Tanaka Muhei

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Ushigome Emi

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Sakabe Kazumi

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Nakanishi Naoko

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Mineoka Yusuke

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Asano Mai

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Yamazaki Masahiro

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Hasegawa Goji

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

• Nakamura Naoto

  Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

抄録

Helicobacter pylori infection, which is a common cause of atrophic gastritis, has been reported to represent a causal factor increasing the vascular damage and consequent albuminuria. On the other hand, decreased serum pepsinogen (PG) I/II ratio can be used to assess gastric mucosal atrophy. To the best of our knowledge, there are no studies investigating the correlation between PG I/II ratio and diabetic nephropathy. Therefore, we investigated a relationship between PG I/II ratio and degree of urinary albumin excretion (UAE) in patients with type 2 diabetes. We evaluated relationships between PG I/II ratio and degree of UAE or estimated glomerular filtration rate as well as various factors, including age, body mass index, blood pressure, hemoglobin A1c, serum lipid concentrations, uric acid or C-reactive protein in 333 consecutive patients with type 2 diabetes. PG I/II ratio correlated positively with logarithm of UAE in all patients (r = 0.174, P = 0.0016) and in patients without Helicobacter pylori infection (r = 0.352, P < 0.0001). Multiple regression analysis identified that PG I/II ratio correlated independently with logarithm of UAE in all patients (β= 0.264, P = 0.0005) and in patients without Helicobacter pylori infection (β= 0.295, P = 0.0022). These data suggest that serum PG I/II ratio is correlated with diabetic nephropathy.

収録刊行物

• Endocrine Journal

  Endocrine Journal 60 (2), 161-166, 2013

  一般社団法人 日本内分泌学会

キーワード

• Pepsinogen
• Albuminuria
• Nephropathy
• Type 2 diabetes

詳細情報

• CRID: 1390282681275095424
• NII論文ID: 10031156736
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.ej12-0244
• COI: 1:STN:280:DC%2BC3s%2FjsF2htQ%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 23047493
• Web Site: https://www.jstage.jst.go.jp/article/endocrj/60/2/60_EJ12-0244/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014000524
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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