Significant interaction between <i>RETN</i> -420 <i>G/G</i> genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese — the J-MICC Study [Rapid Communication]

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  • Hishida Asahi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Wakai Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Okada Rieko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Morita Emi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Hamajima Nobuyuki
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Hosono Satoyo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Higaki Yasuki
    Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka 814-0180, Japan
  • Turin Tanvir Chowdhury
    Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan Department of Medicine, University of Calgary, Calgary, Alberta, Canada
  • Suzuki Sadao
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
  • Motahareh Kheradmand
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Mikami Haruo
    Division of Epidemiology, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
  • Tashiro Naotaka
    Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
  • Watanabe Isao
    Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Katsuura Sakurako
    Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan
  • Kubo Michiaki
    Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan
  • Tanaka Hideo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Naito Mariko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

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Other Title
  • Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese—the J-MICC study.

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Abstract

We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non-DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI<25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.

Journal

  • Endocrine Journal

    Endocrine Journal 60 (2), 237-243, 2013

    The Japan Endocrine Society

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