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- 村藤 俊宏
- Graduate School of Medicine, Yamaguchi University
書誌事項
- タイトル別名
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- Convenient Synthesis of Substituted Azulenes Based on Metalation
- メタルカ ハンノウ ニ ヨル チカン アズレンルイ ノ カンベン ゴウセイ
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抄録
Azulene derivatives have been recognized for their application in medicinal therapy against inflammation. Recently, azulene analogs have been used in optical technology. Nevertheless, synthesis of this family of compounds is always associated with multiple challenges. The reason is attributed to the lack of convenient methods for the synthesis of substituted azulenes. Because of π-electron polarization, azulene undergoes nucleophilic addition at its 4-, 6-, and 8-positions and electrophilic substitution at its 1- and 3-positions. Azulene derivatives bearing substituents at the 2-, 5-, or 7-positions have therefore previously been produced simply by the construction of the azulene skeleton, which introduces the substituent at an early stage of each synthetic method. We describe the convenient synthesis of 2-substituted azulene derivatives from parent azulene 1, a readily available starting material. The technique illustrated here involves various metalation reactions of azulenes.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 71 (3), 217-228, 2013
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680316452736
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- NII論文ID
- 10031157228
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3sXkvVKgs7w%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 024345012
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可