微生物酵素触媒を高度に活用する—合成経路デザインにおける，基質分子工学と触媒探索の重要性—

• 古田 未有

• 花屋 賢悟

• 庄司 満

• 須貝 威

  Department of Pharmaceutical Science, Keio University

書誌事項

タイトル別名

• Towards the Integrated Exploitation of Microbial and Enzymatic Catalysis — Importance of Substrate Molecular Technology and Quest of Biocatalysts, for Designing Synthetic Plans
• 微生物酵素触媒を高度に活用する : 合成経路デザインにおける,基質分子工学と触媒探索の重要性
• ビセイブツ コウソ ショクバイ オ コウド ニ カツヨウ スル : ゴウセイ ケイロ デザイン ニ オケル,キシツ ブンシ コウガク ト ショクバイ タンサク ノ ジュウヨウセイ
• Towards the Integrated Exploitation of Microbial and Enzymatic Catalysis ^|^mdash; Importance of Substrate Molecular Technology and Quest of Biocatalysts, for Designing Synthetic Plans

抄録

Nowadays, biocatalytic, involving microbial and enzymatic, transformations are widely applied for the production of fine chemicals, such as active pharmaceutical ingredients, and for the key reactions for the total synthesis of complex natural products. In this issue, we especially emphasize on two topics, the elaboration on “substrate molecular technology” and “quest of biocatalysts” in our examples of hydrolase-catalyzed kinetic resolution and asymmetric reduction. The aim of this approach is to find the optimized structure and synthetic routes of substrates, which would be maximally advantageous for both selectivity of enzyme-catalyzed reaction, and the total efficiency to target molecules.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 71 (3), 237-246, 2013

  公益社団法人 有機合成化学協会

キーワード

• enzyme catalyst
• kinetic resolution
• hydrolase
• lipase
• hydrolysis
• transesterification
• asymmetric reduction
• whole-cell microorganisms

詳細情報

• CRID: 1390282680316447488
• NII論文ID: 10031157230
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.71.237
• COI: 1:CAS:528:DC%2BC3sXkvVKgs7o%3D
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 024345142
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024345142
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可