Effects of β2-agonists and exercise on β2-adrenergic receptor signaling in skeletal muscles

• Sato Shogo

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University Japan Society for the Promotion of Science

• Shirato Ken

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Kizaki Takako

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• Ohno Hideki

  Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine

• Tachiyashiki Kaoru

  Department of Natural and Living Sciences, Graduate School of Education, Joetsu University of Education

• Imaizumi Kazuhiko

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University Global COE Doctoral Program, Graduate School of Sport Sciences, Waseda University

書誌事項

タイトル別名

• Effects of β₂-agonists and exercise on β₂-adrenergic receptor signaling in skeletal muscles

抄録

In this review, we discuss the anabolic and metabolic responses of skeletal muscles to β₂-agonists and exercise. β₂-agonists increase muscle mass, particularly in fast-twitch muscles. Exercise positively regulates glucose homeostasis, mitochondrial biogenesis, and metabolic enzyme levels in skeletal muscles; whereas treatment with β₂-agonists attenuates these beneficial effects. This review also describes the role of β₂-adrenergic receptor (β₂-AR) signaling molecules, such as cyclic adenosine monophosphate response element-binding protein, mitogen-activated protein kinase, and Akt/protein kinase B, in the response of skeletal muscles to β₂-agonist treatment and exercise. For example, β₂-agonists and exercise increase the phosphorylation of p38 mitogen-activated protein kinase in slow-twitch muscles. Our interpretation of these findings is that β₂-adrenergic receptor signaling plays a functional role in the anabolic and metabolic responses of skeletal muscles to β₂-agonists and exercise.

収録刊行物

• The Journal of Physical Fitness and Sports Medicine

  The Journal of Physical Fitness and Sports Medicine 1 (1), 139-144, 2012

  一般社団法人日本体力医学会

キーワード

• Sports doping
• β₂-agonist clenbuterol
• Exercise
• Skeletal muscle
• β₂-adrenergic receptor signaling

詳細情報

• CRID: 1390001205415877760
• NII論文ID: 10031158935
• NII書誌ID: AA12573156
• DOI: 10.7600/jpfsm.1.139
• ISSN: 21868123
• ISSN: 21868131
• Web Site: https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_139/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014357973
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可