Effects of exercise on the hexosamine biosynthetic pathway and glycosylation

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Author(s)

    • SHIRATO Ken
    • Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
    • KIZAKI Takako
    • Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
    • OHNO Hideki
    • Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine
    • IMAIZUMI Kazuhiko
    • Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

Abstract

Minor amounts of glucose incorporated into the cells is metabolized via the hexosamine biosynthetic pathway, resulting in the production of uridine-5'-diphosphate-<i>N</i>-acetylglucosamine (UDP-GlcNAc), which is utilized as a donor substrate for the <i>N</i>- and <i>O</i>-linked glycosylation of extracellular and membrane proteins in the Golgi apparatus, or for the <i>O</i>-linked GlcNAc modification (<i>O</i>-GlcNAcylation) of intracellular proteins in the cytosol. In particular, <i>O</i>-GlcNAcylation, the addition of GlcNAc to serine/threonine residues, is reversibly regulated by the enzymatic activities of <i>O</i>-GlcNAc transferase (OGT) and <i>O</i>-GlcNAcase. Since OGT activity is sensitive to the intracellular UDP-GlcNAc level, flux via the hexosamine pathway influences <i>O</i>-GlcNAcylation. Actually, excess flux via the hexosamine pathway and resultant increased <i>O</i>-GlcNAcylation are associated with several pathophysiological conditions, including insulin resistance. To date, there are several studies addressing the effects of exercise on the hexosamine pathway and <i>O</i>-GlcNAcylation. Thus, this short review focuses on the relationships among exercise, the hexosamine pathway, <i>O</i>-GlcNAcylation, and insulin resistance.

Journal

  • The Journal of Physical Fitness and Sports Medicine

    The Journal of Physical Fitness and Sports Medicine 1(1), 145-150, 2012-05-01

    The Japanese Society of Physical Fitness and Sports Medicine

References:  51

Codes

  • NII Article ID (NAID)
    10031158936
  • NII NACSIS-CAT ID (NCID)
    AA12573156
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    21868131
  • Data Source
    CJP  J-STAGE 
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