Mechanisms underlying ultraviolet radiation-induced dermal aging

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  • Kawada Shigeo
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo Future Institute for Sport Sciences, Waseda University
  • Nakada Satoshi
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Makanae Yuhei
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

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Abstract

The skin functions as a physical barrier to prevent infection and water evaporation within the body. In addition, it regulates the immune system and produces hormones and neurotransmitters. Because these functions are directly related to whole body health, the maintenance of skin health is important. Sunlight is one of the major inducers of skin damage and includes ultraviolet (UV)-A, UVB, and UVC radiation. UV radiation causes skin aging, so-called photoaging, which is characterized by epidermal hyperplasia, degradation of extracellular matrix molecules, and wrinkle formation. Increasing evidence indicates that UV radiation causes dermal photoaging. In particular, UV radiation-induced dermal angiogenesis is a key factor causing dermal photoaging. This review article describes the molecular mechanisms that underlie UV radiation-induced dermal aging.

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