Alteration in Plasma Endotoxin Level Measured by Endotoxin Scattering Photometry Method in Two Patients with Septic Shock
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- Shimizu Tomoharu
- Department of Surgery, Shiga University of Medical Science
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- Obata Toru
- Department of Surgery, Shiga University of Medical Science
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- Sonoda Hiromichi
- Department of Surgery, Shiga University of Medical Science
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- Akabori Hiroya
- Department of Surgery, Shiga University of Medical Science
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- Miyake Tohru
- Department of Surgery, Shiga University of Medical Science
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- Yamaguchi Tsuyoshi
- Department of Surgery, Shiga University of Medical Science
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- Mori Tsuyoshi
- Department of Surgery, Shiga University of Medical Science
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- Naka Shigeyuki
- Department of Surgery, Shiga University of Medical Science
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- Murata Satoshi
- Department of Surgery, Shiga University of Medical Science
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- Tani Tohru
- Department of Surgery, Shiga University of Medical Science
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Abstract
We report two cases of septic shock in which plasma endotoxins were detected by a novel endotoxin detection method, named endotoxin scattering photometry (ESP) method. Case1: An 85-year-old female was diagnosed with peritonitis caused by sigmoid colon perforation. The patient presented with septic shock after Hartmann’s procedure. Reduction in the elevated endotoxin levels was observed accompanied with the improvement of hemodynamic condition by standard treatment. A temporal elevation of endotoxin at POD3 was observed by ESP but not by turbidimetric method, relating with a decreased blood pressure and requirement of catecholamine. Case2: Since a 73-year-old man with necrotic pancreatitis presented with septic shock, a direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX) was employed. Plasma endotoxins measured by ESP method were markedly reduced by PMX. This reduction of endotoxin measured by ESP method but not by turbidimetric method was related with the improvement of hemodynamic condition. In conclusion, since the alteration in plasma endotoxin measured by ESP method could be in parallel with the improvement of patient’s condition, ESP method may be able to sensitively evaluate endotoxins than the widely used ordinary turbidimetric method. Further study needed to clarify the diagnostic significance of ESP method.
Journal
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- Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)
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Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 38 (1), 75-79, 2013
Japanese College of Surgeons
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Details 詳細情報について
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- CRID
- 1390001204344071936
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- NII Article ID
- 10031162287
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- NII Book ID
- AN00002502
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- ISSN
- 18829112
- 03857883
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed