Animal Models of Autism Spectrum Disorder (ASD) : A Synaptic-Level Approach to Autistic-Like Behavior in Mice

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Abstract

Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders and is thought to be closely associated with genetic factors. It is noteworthy that many ASD-associated genes reported by genome-wide association studies encode proteins related to synaptic formation, transmission, and plasticity. Therefore, it is essential to elucidate the relationship between deficiencies in these genes and the relevant ASD-related phenotypes using synaptic and behavioral phenotypic analysis of mice that are genetically modified for genes related to ASD (e.g., knockout or mutant mice). In this review, we focus on the behavioral-, cellular-, and circuit-level phenotypes, including synaptic formation and function, of several knockout mouse models with genetic mutations related to ASD. Moreover, we introduce our recent findings on the possible association of the dense-core vesicle secretion-related gene <i>CAPS2/CADPS2</i> with ASD by using knockout mice. Finally, we discuss the usefulness and limitations of various mouse models with single gene mutations for understanding ASD.

Journal

  • Experimental Animals

    Experimental Animals 62(2), 71-78, 2013-04-01

    Japanese Association for Laboratory Animal Science

References:  34

Keywords

Codes

  • NII Article ID (NAID)
    10031163545
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    13411357
  • NDL Article ID
    024402136
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  NDL  J-STAGE 
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