Analysis of Odor Compounds in Feces of Mice that Were Exposed to Various Stresses during Breeding
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- SAKUMA Kenji
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan Oriental Giken Inc., 2-9 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 101-0054, Japan
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- HAYASHI Susumu
- Oriental Giken Inc., 2-9 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 101-0054, Japan
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- YASAKA Yoshiyuki
- Oita Laboratory, Sumika Chemical Analysis Service, Ltd., 2200 Tsurusaki, Oita-shi, Oita 870-0106, Japan
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- NISHIJIMA Hiroto
- Oita Laboratory, Sumika Chemical Analysis Service, Ltd., 2200 Tsurusaki, Oita-shi, Oita 870-0106, Japan
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- FUNABASHI Hisakage
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan Present address: Institute for Sustainable Science and Development, Hiroshima University, 2-313 Kagamiyama, Higashihiroshima, Hiroshima 739-8527, Japan
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- HAYASHI Masayoshi
- Oriental Giken Inc., 2-9 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 101-0054, Japan
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- MATSUOKA Hideaki
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
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- SAITO Mikako
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
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Abstract
In order to provide healthy experimental animals, it is important to find and remove animals that have been accidentally exposed to various stresses during breeding. This study focuses mouse health-care management. Here we used human olfaction and gas chromatography-mass spectrometry to assess odor intensity and determine the concentrations of odor components. The feces were collected from mice that were exposed to 4 different stresses (no bedding chips, shaking, fasting, and movement restriction). These stresses caused a change in odor intensity as assessed by 6 panelists. Seventeen components were identified as dominant components in the odor that was emitted from feces. The concentration of each compound was converted to relative values versus its odor threshold levels in order to select ones effective for the quality of the odor. As a result, 12 selected components were found to be a useful set for the recognition of mice bred under different stress conditions. The present results may provide useful information for the development of standard fecal odor materials that may be used for the training of mouse care personnel.
Journal
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- Experimental Animals
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Experimental Animals 62 (2), 101-107, 2013
Japanese Association for Laboratory Animal Science
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Details 詳細情報について
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- CRID
- 1390282680022098176
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- NII Article ID
- 10031163549
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- NII Book ID
- AA11032321
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- COI
- 1:STN:280:DC%2BC3srot1ahuw%3D%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 024402315
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- PubMed
- 23615304
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed