Encephalitis associated with positive anti-GluR antibodies showing abnormal appearance in basal ganglia, pulvinar and gray matter on MRI -Case report

DOI Web Site 16 References
  • Saito Toshio
    Division of Neurology, National Hospital Organization Toneyama National Hospital
  • Saito Tomoko
    Division of Neurology, National Hospital Organization Toneyama National Hospital
  • Takahashi Yukitoshi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
  • Kokunai Yosuke
    Department of Neurology, Osaka University Graduate School of Medicine
  • Fujimura Harutoshi
    Division of Neurology, National Hospital Organization Toneyama National Hospital

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Other Title
  • 脳ＭＲＩで大脳基底核，視床枕，後頭・側頭葉皮質病変を呈し，抗グルタミン酸受容体抗体が陽性であった若年女性脳炎の１例
  • 症例報告 脳MRIで大脳基底核,視床枕,後頭・側頭葉皮質病変を呈し,抗グルタミン酸受容体抗体が陽性であった若年女性脳炎の1例
  • ショウレイ ホウコク ノウ MRI デ ダイノウ キテイカク シショウチン コウトウ ソクトウ ヨウ ヒシツ ビョウヘン オ テイシ コウグルタミンサン ジュヨウタイ コウタイ ガ ヨウセイ デ アッタ ジャクネン ジョセイ ノウエン ノ 1レイ

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Abstract

We treated a 25-year-old woman with encephalitis. Following delivery, the patient developed fever, consciousness disturbance, cognitive dysfunction, and progressive motor dysfunction. In addition, mycobacterium tuberculosis was found in the lung, though there was no evidence of such infection in the central nervous system. Cerebrospinal fluid analysis revealed a slight elevation of mononuclear cells with a normal protein level, indicating a possible viral infection. We could not find the origin of the infection, though the serum anti-glutamate ε2 receptor antibody was positive. Intravenous administration of methylprednisolone (1,000mg/day for 3 days) was temporarily effective for improvement of the clinical signs and symptoms. However, she finally demonstrated rapid deterioration resulting in death. Diffusion-weighted brain magnetic resonance imaging demonstrated abnormal high intensity lesions in the bilateral pulvinar and gray matter, with an abnormal appearance mimicking pulvinar sign.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 51 (3), 192-196, 2011

    Societas Neurologica Japonica

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