A case of clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with anti-glutamate receptor antibody

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  • 抗グルタミン酸受容体抗体陽性を示した可逆性脳梁膨大部病変を有する脳症の１例
  • コウグルタミンサン ジュヨウタイ コウタイ ヨウセイ オ シメシタ カギャクセイ ノウリョウボウダイブ ビョウヘン オ ユウスル ノウショウ ノ 1レイ

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Abstract

We report the case of an 18-year-old boy who presented with disturbance of consciousness and generalized seizures following flu-like symptoms such as high fever and arthralgia. T2 and diffusion weighted brain magnetic resonance images showed a hyperintense ovoid lesion in the splenium of the corpus callosum and T1 weighted images showed a hypointense lesion; the lesion completely disappeared on repeat imaging after 3 days. Anti-glutamate ε2 receptor antibodies were detected in his cerebrospinal fluid. Although the patient had several episodes of generalized seizures, he completely recovered within 3 months. Our patient had a clinically mild encephalitis/encephalopathy with a reversible splenial lesion following flu-like symptoms, which indicated viral infection. As compared to previously reported cases, our case was characteristic because of the protracted recovery shown by the patient. Anti-glutamate ε2 receptor antibodies may be associated with prolonged generalized seizures in the case of our patient. Our results also suggest that anti-glutamate ε2 receptor antibodies may play a role in the pathogenesis of this condition.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 51 (7), 510-513, 2011

    Societas Neurologica Japonica

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