Immunization of Rabbits with Nematode Ascaris lumbricoides Antigens Induces Antibodies Cross-Reactive to House Dust Mite Dermatophagoides farinae Antigens

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Author(s)

    • SAITO Akemi
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • FUKUTOMI Yuma
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • TAKAI Toshiro
    • Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
    • YUNUS Md
    • International Center for Diarrheal Disease Research
    • TAKEUCHI Haruko
    • Faculty of Health and Social Work, Human Development and Basic Science, Kanagawa University of Human Services
    • IWATA Tsutomu
    • Division of Pediatric Science, Department of Child Health and Development, Tokyo Kasei University
    • AKIYAMA Kazuo
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

Abstract

There are controversial reports on the relationship between helminthic infection and allergic diseases. Although IgE cross-reactivity between nematode <i>Ascaris</i> antigens and house dust-mite allergens in allergic patients have been reported, whether <i>Ascaris</i> or the mite is the primary sensitizer remains unknown. Here we found that immunization of naïve animals with <i>Ascaris lumbricoides</i> (Al) antigens induced production of antibodies cross-reactive to mite antigens from <i>Dermatophagoides farinae</i> (Df). Sera from Bangladeshi children showed IgE reactivity to <i>Ascaris</i> and mite extracts. IgG from rabbits immunized with Al extract exhibited reactivity to Df antigens. Treatment of the anti-Al antibody with Df antigen-coupled beads eliminated the reactivity to Df antigens. In immunoblot analysis, an approximately 100-kDa Df band was the most reactive to anti-Al IgG. The present study is the first step towards the establishment of animal models to study the relationship between <i>Ascaris</i> infection and mite-induced allergic diseases.

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 77(1), 145-150, 2013-01-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Codes

  • NII Article ID (NAID)
    10031164704
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09168451
  • NDL Article ID
    024226682
  • NDL Call No.
    Z53-G223
  • Data Source
    CJP  NDL  J-STAGE 
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