Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine

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  • MURAKAMI Itsuo
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University
  • MITSUTAKE Susumu
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University
  • KOBAYASHI Naoyuki
    Frontier Laboratories of Value Creation, Sapporo Breweries, Ltd.
  • MATSUDA Junko
    Institute of Glycoscience, Tokai University
  • SUZUKI Akemi
    Institute of Glycoscience, Tokai University
  • SHIGYO Tatsuro
    Frontier Laboratories of Value Creation, Sapporo Breweries, Ltd.
  • IGARASHI Yasuyuki
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University

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Abstract

We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.

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