【Original Contribution】 Preparation of Multiple Emulsions to Depress the Release of Drugs and Enhanced Permeation Effect in Transdermal Delivery
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- Abe Yuko
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- Tahara Yoshiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- Wakabayashi Rie
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- Kamiya Noriho
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University Center for Future Chemistry, Kyushu University
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- Goto Masahiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University Center for Future Chemistry, Kyushu University SO Pharmaceutical Corporation
Bibliographic Information
- Other Title
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- 【原著】 薬物漏洩を制御した多層エマルションの調製と経皮吸収促進効果
- 薬物漏洩を制御した多層エマルションの調製と経皮吸収促進効果
- ヤクブツ ロウエイ オ セイギョ シタ タソウ エマルション ノ チョウセイ ト ケイヒ キュウシュウ ソクシン コウカ
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Abstract
A transdermal drug delivery system (TDDS) has attracted much attention due to several advantages over the other administration routes such as injection from the viewpoint of a less harmful method and avoiding first pass through liver. However, its real drug application has been limited to small or lipophilic drugs that can be permeated through the stratum corneum, which has a strong barrier function. Here, we focused on Solid-in-Oil-in-Water (S/O/W) emulsions as a novel TDDS carrier. This technique can encapsulate large hydrophilic molecules such as oligopeptides, proteins and DNAs in the inner oil phase of Oil-in-Water (O/W) emulsion by coating the hydrophilic macromolecules with surfactant molecules. Dispersing hydrophilic macromolecular drugs into the oil phase, S/O/W emulsion containing the hydrophilic drugs can raise the affinity and distribute to the hydrophobic stratum corneum. In this study, we encapsulated hydrophilic macromolecules into S/O/W and investigated the penetration behavior of hydrophilic macromolecules through the skin.
Journal
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- MEMBRANE
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MEMBRANE 38 (2), 92-96, 2013
THE MEMBRANE SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282681398930176
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- NII Article ID
- 10031165414
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- NII Book ID
- AN0023215X
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- COI
- 1:CAS:528:DC%2BC3sXhtVaht7fP
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- ISSN
- 18846440
- 03851036
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- NDL BIB ID
- 024608632
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed