pH Sensitive Structural Transition of Cationic Micelles Made from a Sugar-Bearing Lipid

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  • MATSUO Takuma
    Department of Chemistry and Biochemistry, Faculty of Engineering, The University of Kitakyushu
  • FUJII Shota
    Department of Chemistry and Biochemistry, Faculty of Engineering, The University of Kitakyushu
  • SANADA Yusuke
    Department of Chemistry and Biochemistry, Faculty of Engineering, The University of Kitakyushu
  • SAKURAI Kazuo
    Department of Chemistry and Biochemistry, Faculty of Engineering, The University of Kitakyushu

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Other Title
  • 糖アルコールを有するカチオン性ミセルのpH応答性による構造転移
  • トウ アルコール オ ユウスル カチオンセイ ミセル ノ pH オウトウセイ ニ ヨル コウゾウ テンイ

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Abstract

Amphiphilic compounds can aggregate to form micelles with various structures in aqueous solutions. Especially cationic lipids can complex with DNA, therefore they are expected to work as gene carriers for drug delivery systems (DDS). However, it is difficult to control the structures of micelles. In this study, we synthesized a cationic lipid with C12 alkyl chain and measured the structure of the micelles with small angle X-ray scattering (SAXS) at various pH. SAXS showed a structural transition from cylinder to lamellar structure between low pH and high pH. We confirmed these results by Transmission Electron Microscope (TEM). These results proof that this cationic lipid undergoes a pH dependent structural transition.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 70 (4), 140-144, 2013

    The Society of Polymer Science, Japan

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