Drug Treatment of Chronic Kidney Disease in Dental Office
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- YAMADA Shoji
- Department of Pharmacology, Showa University School of Dentistry
Bibliographic Information
- Other Title
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- 慢性腎臓病 (CKD) 患者への歯科薬物療法—薬物動態学的考察—
- 慢性腎臓病(CKD)患者への歯科薬物療法 : 薬物動態学的考察
- マンセイ ジンゾウビョウ(CKD)カンジャ エ ノ シカ ヤクブツ リョウホウ : ヤクブツ ドウタイガクテキ コウサツ
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Abstract
Chronic kidney disease (CKD) is one of the wide prevalent disease, and it is not negligible that a dentist have a chance to prescribe an antibiotics for a CKD patient with a low kidney function. Beta-lactam antibiotics, such as penicillin antibiotics or cephem antibiotics, are most frequently prescribed drugs in dental office. Most dentists will be careful about allergic adverse effects of beta-lactam antibiotics, but only a few dentists will recognize that beta-lactam antibiotics are excrete mainly from kidney, and that these drugs are recommended to adjust the dosing schedule for the patient with a low kidney function. If you administer a renally-eliminated drug repeatedly for the CKD patient with an elongated half-life, the mean plasma drug concentration in stable phase will increase to toxic concentration. Pharmacokinetically-guided correction coefficient will be helpful to get an adequate dosing schedule for the patient with a low kidney function. The reference chart of recommended dosing schedule for the CKD patients will also be helpful.
Journal
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- Dental Medicine Research
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Dental Medicine Research 33 (1), 43-50, 2013
Showa University Dental Society
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Details 詳細情報について
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- CRID
- 1390282680433595904
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- NII Article ID
- 10031166793
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- NII Book ID
- AA12322983
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- COI
- 1:CAS:528:DC%2BC3sXhtV2mu7bL
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- ISSN
- 2186540X
- 18820719
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- NDL BIB ID
- 024780346
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed