Association of Serum Carotenoid Levels With N-Terminal Pro-Brain-Type Natriuretic Peptide : A Cross-Sectional Study in Japan

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Author(s)

    • SUZUKI Koji
    • Department of Public Health, Fujita Health University School of Health Sciences
    • ISHII Junichi
    • Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine
    • KITAGAWA Fumihiko
    • Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital
    • KUNO Atsuhiro
    • Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital
    • KUSUHARA Yasuhiro
    • Department of Medical Zoology, Fujita Health University School of Health Sciences
    • OCHIAI Junichi
    • Department of Medical Electronics, Fujita Health University School of Health Sciences
    • ICHINO Naohiro
    • Department of Clinical Physiology, Fujita Health University School of Health Sciences
    • OSAKABE Keisuke
    • Department of Clinical Physiology, Fujita Health University School of Health Sciences
    • SUGIMOTO Keiko
    • Department of Clinical Physiology, Fujita Health University School of Health Sciences
    • YAMADA Hiroya
    • Department of Hygiene, Fujita Health University School of Medicine
    • ITO Yoshinori
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • HAMAJIMA Nobuyuki
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • INOUE Takashi
    • Department of Public Health, Fujita Health University School of Health Sciences

Abstract

<b>Background: </b>Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population.<BR><b>Methods: </b>In this cross-sectional study, we investigated whether serum carotenoids were associated with serum NT-proBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay.<BR><b>Results: </b>Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum α-carotene and elevated NT-proBNP in men (odds ratio [OR] = 0.40, 95% CI = 0.19–0.82, <i>P</i> for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39–0.99, <i>P</i> for trend = 0.047). In women, moreover, elevated serum NT-proBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36–0.90 for highest quartile, <i>P</i> for trend = 0.026) and β-cryptoxanthin (OR = 0.53, 95% CI = 0.32–0.85 for highest quartile, <i>P</i> for trend = 0.026), after adjusting for potential confounders.<BR><b>Conclusions: </b>Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 23(3), 163-168, 2013-05-01

    Japan Epidemiological Association

References:  47

Codes

  • NII Article ID (NAID)
    10031167774
  • NII NACSIS-CAT ID (NCID)
    AA10952696
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09175040
  • Data Source
    CJP  J-STAGE 
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