Association of Serum Carotenoid Levels With N-Terminal Pro-Brain-Type Natriuretic Peptide: A Cross-Sectional Study in Japan

• Suzuki Koji

  Department of Public Health, Fujita Health University School of Health Sciences

• Ishii Junichi

  Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine

• Kitagawa Fumihiko

  Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital

• Kuno Atsuhiro

  Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital

• Kusuhara Yasuhiro

  Department of Medical Zoology, Fujita Health University School of Health Sciences

• Ochiai Junichi

  Department of Medical Electronics, Fujita Health University School of Health Sciences

• Ichino Naohiro

  Department of Clinical Physiology, Fujita Health University School of Health Sciences

• Osakabe Keisuke

  Department of Clinical Physiology, Fujita Health University School of Health Sciences

• Sugimoto Keiko

  Department of Clinical Physiology, Fujita Health University School of Health Sciences

• Yamada Hiroya

  Department of Hygiene, Fujita Health University School of Medicine

• Ito Yoshinori

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Hamajima Nobuyuki

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Inoue Takashi

  Department of Public Health, Fujita Health University School of Health Sciences

抄録

Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population.<BR>Methods: In this cross-sectional study, we investigated whether serum carotenoids were associated with serum NT-proBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay.<BR>Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum α-carotene and elevated NT-proBNP in men (odds ratio [OR] = 0.40, 95% CI = 0.19–0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39–0.99, P for trend = 0.047). In women, moreover, elevated serum NT-proBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36–0.90 for highest quartile, P for trend = 0.026) and β-cryptoxanthin (OR = 0.53, 95% CI = 0.32–0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders.<BR>Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 23 (3), 163-168, 2013

  日本疫学会

キーワード

• carotenoids
• N-terminal pro-brain-type natriuretic peptide
• cross-sectional study

詳細情報

• CRID: 1390001204475821568
• NII論文ID: 10031167774
• NII書誌ID: AA10952696
• DOI: 10.2188/jea.je20120087
• COI: 1:STN:280:DC%2BC3svks1Wrug%3D%3D
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 23474820
• Web Site: https://www.jstage.jst.go.jp/article/jea/23/3/23_JE20120087/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014163858
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
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