Myoepithelial carcinoma of the sublingual gland:a case report

DOI 31 References
  • Niimi Kanae
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
  • Shingaki Susumu
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
  • Nakazato Takayuki
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
  • Cheng Jung
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
  • Nishiyama Hideyoshi
    Division of Oral and Maxillofacial Radiology, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
  • Saito Chikara
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences

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  • 舌下腺に発生した筋上皮癌の1例

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Abstract

Myoepithelial carcinoma (MEC), a rare malignant salivary gland tumor, was first classified as a separate neoplasm by the World Health Organization (WHO) in 1991. The tumor represents less than 1% of all salivary gland neoplasms. MEC occurs most frequently in the parotid gland (75%), and approximately 10% in the submandibular gland, and there have been no previous reports of MEC arising from the sublingual gland. Herein, we report a case of MEC occurring in the sublingual gland.<br>A 67-year-old male came to our hospital in January of 2006, complaining of a swelling on the left side of the floor of the mouth. Clinical examination revealed a 30 × 20 × 10mm elastic, hard, non-tender, submucosal mass on the left side of the floor of the mouth. The mass had poor mobility, but no ulceration was seen on the surface of the mucosa.<br>Magnetic resonance imaging (MRI) showed an ovoid form mass with a bright mixture of hyper- and hypo-intense signals on T1-weighted images. No signs of mandibular bone invasion were detected. The resected specimen showed a lobulated shape and it extended from the sublingual gland into the surrounding tissues. Immunohistochemical analysis indicated that the tumor cells were positive for S-100 protein, SMA, pan-keratin, CK19, MUC-I, Calponin, and Vimentin. The pathological diagnosis was myoepithelial carcinoma of the sublingual gland. During the follow-up for 2 years and 9 months, there was no clinical or radiological evidence of loco-regional recurrence or distant metastasis.

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