Effects of Exposure to Nanoparticle-rich Diesel Exhaust on Pregnancy in Rats

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Author(s)

    • ZHANG Yonghui
    • College of Animal Science and Technology, Nanjing Agricultural University
    • FUJITANI Yuji
    • Research Center for Environmental Risk, National Institute for Environmental Studies
    • NAGAOKA Kentaro
    • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • WATANABE Gen
    • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • TAYA Kazuyoshi
    • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

Abstract

Pollutants from burning of diesel fuel are hazardous to human health. Nanoparticles in diesel exhaust potentially have profound impact on fetal development and maternal endocrine function during pregnancy due to their ability to penetrate deeply into the body. To investigate the effects of nanoparticle-rich diesel exhaust (NR-DE) on pregnancy, pregnant rats were exposed to NR-DE, filtered diesel exhaust (F-DE) or clean air for 19 days of gestation. Relative weights of maternal liver and spleen to body weight were significantly lower in the NR-DE and F-DE groups than those in the control group. The serum concentration of maternal progesterone was significantly lower, while those of luteinizing hormone (LH) and corticosterone were significantly higher in the NR-DE and F-DE groups than those in the control group. The serum concentration of estradiol-17β was significantly higher in the F-DE group than that in the control group. The levels of cytochrome P450 side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase and LH receptor mRNA in the corpus luteum were significantly lower in the NR-DE and F-DE groups than those in the control. In fetuses, body weight and crown-rump length were significantly greater and shorter, respectively, in both males and females in the NR-DE and F-DE groups than those in the control group. These results demonstrate that exposure of pregnant rats to NR-DE and F-DE suppresses the function of corpora lutea and stimulates the function of the adrenal cortex, suggesting a risk of spontaneous abortion associated with maternal hormonal changes.

Journal

  • Journal of Reproduction and Development

    Journal of Reproduction and Development 59(2), 145-150, 2013-04-01

    THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

References:  47

Codes

  • NII Article ID (NAID)
    10031170772
  • NII NACSIS-CAT ID (NCID)
    AA10936678
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09168818
  • NDL Article ID
    024426221
  • NDL Call No.
    Z54-H305
  • Data Source
    CJP  NDL  J-STAGE 
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