Evaluation of Harmonic Signals from Magnetic Nanoparticles and Application to Magnetic Nanoparticle Imaging
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- Yoshida Takashi
- Kyushu University
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- Othman Nurmiza Binti
- Kyushu University
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- Tsubaki Takuya
- Kyushu University
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- Enpuku Keiji
- Kyushu University
Bibliographic Information
- Other Title
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- 磁気ナノ粒子の高調波特性評価と磁気粒子イメージングへの応用
- ジキ ナノ リュウシ ノ コウチョウハ トクセイ ヒョウカ ト ジキ リュウシ イメージング エ ノ オウヨウ
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Abstract
We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. Since the interference of the excitation field can be significantly decreased by measuring the harmonic signals, the detection sensitivity can be improved. First, we have characterized the nonlinear properties of MNPs in order to evaluate the harmonic signals. We clarified what proportion of MNPs contributes to the harmonic signal. It is important to choose a sample having a large portion of MNPs with large magnetic moment and short relaxation time for the harmonic signal-based detection. Then, we measured a contour map of the signal field from the MNPs with our simple detection system using second harmonic signal. We could detect 100μg of MNPs located at z=25mm below the pickup coil with a high signal-to-noise ratio. Analyzing the contour map using a mathematical technique called singular value decomposition (SVD), we could clearly distinguish two MNP samples separated by Δx=25mm and located at z=25mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.
Journal
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- IEEJ Transactions on Fundamentals and Materials
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IEEJ Transactions on Fundamentals and Materials 133 (6), 344-350, 2013
The Institute of Electrical Engineers of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679577137920
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- NII Article ID
- 10031175271
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- NII Book ID
- AN10136312
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- ISSN
- 13475533
- 03854205
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- NDL BIB ID
- 024698393
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed