Structure-Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

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Author(s)

    • SATO Mizuho
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • MURAKAMI Kazuma
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • UNO Mayumi
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • IKUBO Haruko
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • NAKAGAWA Yu
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • IRIE Kazuhiro
    • Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Abstract

Silymarin, the seed extract of <i>Silybium marianum</i>, has preventive effects against Alzheimer's disease-like pathogenesis <i>in vivo</i>. We isolated (+)-taxifolin (<b>4</b>) from silymarin as an inhibitor of aggregation of the 42-residue amyloid β-protein. Structure-activity relationship studies revealed the 3',4'-dihydroxyl groups to be critical to the anti-aggregative ability, whereas the 7-hydroxyl group and the stereochemistry at positions 2 and 3 were not important.

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 77(5), 1100-1103, 2013-05-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Codes

  • NII Article ID (NAID)
    10031177604
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    09168451
  • Data Source
    CJP  J-STAGE 
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