Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H₁-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

• Kuroda Wakana

  Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Kitamura Yoshiaki

  Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Mizuguchi Hiroyuki

  Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Miyamoto Yuko

  Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Kalubi Bukasa

  Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Fukui Hiroyuki

  Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

• Takeda Noriaki

  Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

Bibliographic Information

Other Title

• Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H₁-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

Abstract

An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H₁–receptor (H1R) mRNA in toluene 2,4-diisocyanate (TDI)-sensitized rats. Although pre-treatment with pranlukast partially, but significantly, suppressed TDI-induced up-regulation of H1R mRNA and nasal symptoms, pre-treatment with the combination of pranlukast and chlorpheniramine significantly suppressed them in a manner greater than either drug alone. These findings suggest that the additive therapeutic effect of the combination of LTR antagonist and antihistamine is due to their additive suppression of H1R up-regulation.

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 122 (1), 55-58, 2013

  The Japanese Pharmacological Society

Keywords

• antihistamine
• cysteinyl leukotoriene receptor antagonist
• histamine H₁-receptor

Details

• CRID: 1390001205179119488
• NII Article ID: 10031177881
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.12250sc
• COI: 1:CAS:528:DC%2BC3sXovVeltLY%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 024518205
• PubMed: 23615224
• Web Site: http://id.ndl.go.jp/bib/024518205
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024518205
• Web Site: https://www.jstage.jst.go.jp/article/jphs/122/1/122_12250SC/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014028161
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed