Regulation of skeletal muscle GLUT-4 expression by exercise and nutritional stimuli
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- Higashida Kazuhiko
- Faculty of Sport Sciences, Waseda University
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- Tabata Izumi
- Faculty of Sport and Health Science, Ritsumeikan University
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- Higuchi Mitsuru
- Faculty of Sport Sciences, Waseda University
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- Terada Shin
- Department of Life Sciences, Graduate School or Arts and Sciences, The University of Tokyo
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抄録
Skeletal muscle is the primary site of glucose uptake in humans. Glucose transport activity, which is the rate-limiting step in muscle glucose metabolism, is linearly related to the content of the GLUT-4 isoform of the glucose transporter. Therefore, the level of GLUT-4 in skeletal muscle may be an important determinant of whole-body glucose disposal. It has been well documented that long-term, low- to moderate-intensity endurance exercise training induces an increase in muscle GLUT-4 content. However, emerging evidence suggests that an adaptive increase in GLUT-4 occurs even after a single acute bout of exercise or high-intensity intermittent exercise training. Recent findings also indicate that nutritional status affects GLUT-4 expression in skeletal muscle. This review provides an overview of the effects of exercise and nutritional status on GLUT-4 content in skeletal muscle, and summarizes recent progress in elucidating the molecular regulation of muscle GLUT-4 gene expression by exercise and nutritional stimuli.
収録刊行物
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- The Journal of Physical Fitness and Sports Medicine
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The Journal of Physical Fitness and Sports Medicine 2 (3), 355-360, 2013
一般社団法人日本体力医学会
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詳細情報 詳細情報について
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- CRID
- 1390282680393324544
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- NII論文ID
- 10031179361
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- NII書誌ID
- AA12573156
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- ISSN
- 21868123
- 21868131
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- NDL書誌ID
- 024738349
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可