The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma
-
- Hayashi Atsushi
- Department of Medical Technology, Graduate School of Health Science, Okayama University Department of Pathology, Okayama Red Cross Hospital
-
- Fumon Takumi
- Department of Medical Technology, Graduate School of Health Science, Okayama University
-
- Miki Yukari
- Department of Medical Technology, Graduate School of Health Science, Okayama University Department of Medical Technology, Kagawa Prefectural University of Health Science
-
- Sato Hiaki
- Department of Medical Technology, Graduate School of Health Science, Okayama University
-
- Yoshino Tadashi
- Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
-
- Takahashi Kiyoshi
- Department of Medical Technology, Graduate School of Health Science, Okayama University
この論文をさがす
抄録
Thymic carcinoma (TC) is often very difficult to distinguish from type B3 thymoma and lung squamous cell carcinoma (L-SCC) involving the anterior mediastinum. The present study evaluated the usefulness of immunohistochemical markers including c-Kit, CD5, glucose transporter-1 (GLUT-1), claudin-1 (CLDN-1), thymoproteasome β5t, p53 and Ki-67 (MIB-1) and thymic cortical environmental marker cells, cortical thymocytes (c-Thy) and thymic cortical dendritic macrophages (TCDMs) in distinguishing thymic carcinoma (TC) from type B3 thymoma or lung squamous cell carcinoma (L-SCC) using 17 cases of type B3 thymoma, 18 cases of TC and 12 cases of L-SCC. The results indicated that c-Kit and CD5 are very useful markers for TC, while GLUT-1, CLDN-1, p53 and Ki-67 are not. Thymic cortical microenvironmental marker cells, especially TCDMs, and thymic cortical epithelial cell-marker β5t are also useful for distinguishing TC from type B3 thymoma. Although none of these markers are adequate for making a distinction when used alone, the plural use of c-Kit, CD5, β5t thymic cortical environmental marker cells, c-Thys and TCDMs may therefore lead to a correct distinction between TC and type B3 thymoma or L-SCC. [J Clin Exp Hematop 53(1) : 9-19, 2013]
収録刊行物
-
- Journal of Clinical and Experimental Hematopathology
-
Journal of Clinical and Experimental Hematopathology 53 (1), 9-19, 2013
日本リンパ網内系学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679682662272
-
- NII論文ID
- 10031183122
-
- NII書誌ID
- AA11556796
-
- COI
- 1:STN:280:DC%2BC3sjlslaitQ%3D%3D
-
- ISSN
- 18809952
- 13464280
-
- PubMed
- 23801129
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可