Intensity Correction Method Customized for Multi-animal Abdominal MR Imaging with 3T Clinical Scanner and Multi-Array Coil
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- MITSUDA Minoru
- Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East Graduate School of Human Health Sciences, Tokyo Metropolitan University
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- YAMAGUCHI Masayuki
- Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East
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- NAKAGAMI Ryutaro
- Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East Graduate School of Human Health Sciences, Tokyo Metropolitan University Research Fellow of the Japan Society for the Promotion of Science
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- FURUTA Toshihiro
- Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East Radiology and Biomedical Engineering, Graduate School of Medicine, The University of Tokyo
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- SEKINE Norio
- Graduate School of Human Health Sciences, Tokyo Metropolitan University
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- NIITSU Mamoru
- Department of Radiology, Saitama Medical University
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- MORIYAMA Noriyuki
- Research Center for Cancer Prevention and Screening, National Cancer Center
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- FUJII Hirofumi
- Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East
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抄録
Purpose: Simultaneous magnetic resonance (MR) imaging of multiple small animals in a single session increases throughput of preclinical imaging experiments. Such imaging using a 3-tesla clinical scanner with multi-array coil requires correction of intensity variation caused by the inhomogeneous sensitivity profile of the coil. We explored a method for correcting intensity that we customized for multi-animal MR imaging, especially abdominal imaging.<br> Method: Our institutional committee for animal experimentation approved the protocol. We acquired high resolution T1-, T2-, and T2*-weighted images and low resolution proton density-weighted images (PDWIs) of 4 rat abdomens simultaneously using a 3T clinical scanner and custom-made multi-array coil. For comparison, we also acquired T1-, T2-, and T2*-weighted volume coil images in the same rats in 4 separate sessions. We used software created in-house to correct intensity variation. We applied thresholding to the PDWIs to produce binary images that displayed only a signal-producing area, calculated multi-array coil sensitivity maps by dividing low-pass filtered PDWIs by low-pass filtered binary images pixel by pixel, and divided uncorrected T1-, T2-, or T2*-weighted images by those maps to obtain intensity-corrected images. We compared tissue contrast among the liver, spinal canal, and muscle between intensity-corrected multi-array coil images and volume coil images.<br> Results: Our intensity correction method performed well for all pulse sequences studied and corrected variation in original multi-array coil images without deteriorating the throughput of animal experiments. Tissue contrasts were comparable between intensity-corrected multi-array coil images and volume coil images.<br> Conclusion: Our intensity correction method customized for multi-animal abdominal MR imaging using a 3T clinical scanner and dedicated multi-array coil could facilitate image interpretation.<br>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 12 (2), 95-103, 2013
日本磁気共鳴医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205194854400
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- NII論文ID
- 10031183922
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- NII書誌ID
- AA11648770
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- COI
- 1:STN:280:DC%2BC3snjtFShuw%3D%3D
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- ISSN
- 18802206
- 13473182
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- PubMed
- 23666151
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可