Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte

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Author(s)

    • FUJIKURA Junji
    • Division of Endocrinology and Metabolism, Kyoto University Hospital,
    • HOSODA Kiminori
    • Department of Human Health Science, Kyoto University Graduate School of Medicine
    • NAKAO Kazuwa
    • Division of Endocrinology and Metabolism, Kyoto University Hospital,

Abstract

Experimental transplantation of endocrine tissues has led to significant advances in our understanding of endocrinology and metabolism. Endocrine cell transplantation therapy is expected to be applied to the treatment of metabolic endocriopathies. Restoration of functional pancreatic beta-cell mass or of functional adipose mass are reasonable treatment approaches for patients with diabetes or lipodystrophy, respectively. Human induced pluripotent stem (iPS) cell research is having a great impact on life sciences. Doctors Takahashi and Yamanaka discovered that the forced expression of a set of genes can convert mouse and human somatic cells into a pluripotent state [1, 2]. These iPS cells can differentiate into a variety of cell types. Therefore, iPS cells from patients may be a potential cell source for autologous cell replacement therapy. This review briefly summarizes the current knowledge about transplantation therapy for diabetes mellitus, the development of the endocrine pancreas and adipocytes, and endocrine-metabolic disease-specific iPS cells.

Journal

  • Endocrine Journal

    Endocrine Journal 60(6), 697-708, 2013-06-01

    The Japan Endocrine Society

References:  162

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