Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

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  • KURISU Manami
    Graduate School of Life and Environmental Sciences, University of Tsukuba
  • MIYAMAE Yusaku
    Graduate School of Biostudies, Kyoto University
  • MURAKAMI Kazuma
    Graduate School of Agriculture, Kyoto University
  • HAN Junkyu
    Graduate School of Life and Environmental Sciences, University of Tsukuba Alliance for Research on North Africa, University of Tsukuba
  • ISODA Hiroko
    Graduate School of Life and Environmental Sciences, University of Tsukuba Alliance for Research on North Africa, University of Tsukuba
  • IRIE Kazuhiro
    Graduate School of Agriculture, Kyoto University
  • SHIGEMORI Hideyuki
    Graduate School of Life and Environmental Sciences, University of Tsukuba

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We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

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