Stereoselective Synthesis of a Promising Flower-Inducing KODA Analog, (9R,12S,13R,15Z)-9-Hydroxy-12,13-methylene-10-oxooctadec-15-enoic Acid

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  • SHIMOMURA Shin
    Department of Bioresource Science, College of Agriculture, Ibaraki University
  • OYAMA Shuho
    Department of Bioresource Science, College of Agriculture, Ibaraki University
  • NAKANO Kyohei
    Department of Bioresource Science, College of Agriculture, Ibaraki University
  • HASEGAWA Morifumi
    Department of Bioresource Science, College of Agriculture, Ibaraki University
  • TOSHIMA Hiroaki
    Department of Bioresource Science, College of Agriculture, Ibaraki University

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  • Stereoselective Synthesis of a Promising Flower-Inducing KODA Analog, (9<i>R</i>,12<i>S</i>,13<i>R</i>,15<i>Z</i>)-9-Hydroxy-12,13-methylene-10-oxooctadec-15-enoic Acid

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Stereoselective synthesis of a promising flower-inducing 9,10-ketol octadecadienoic acid (KODA) analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid, was designed to obtain the desired stereoisomer via coupling between chiral sulfone and aldehyde segments. A known chiral cyclopropane derivative was converted to the sulfone segment via carbon-chain elongation and sulfonylation. Dec-9-en-1-ol was converted to the aldehyde segment, whose C-9 configuration was introduced by Sharpless asymmetric dihydroxylation. Coupling of the both segments and subsequent assembly gave the desired (9R,12S,13R,15Z)-analog. The (9S,12S,13R,15Z)-analog was also synthesized by using the enatiomeric aldehyde segment. This strategy made it possible to synthesize the remaining stereoisomeric analogs.

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