Tandospirone Suppresses Impulsive Action by Possible Blockade of the 5-HT_<1A> Receptor

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Author(s)

Abstract

Higher impulsivity is observed in several psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. Although the involvement of the 5-HT<sub>1A</sub> receptor in impulsive behavior has been indicated, the effects of clinically relevant drugs have been rarely tested. In the present study, we examined whether (3a<i>R</i>,4<i>S</i>,7<i>R</i>,7a<i>S</i>)-rel-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride (tandospirone), an anxiolytic and a partial agonist of the 5-HT<sub>1A</sub> receptor, could affect impulsive action in the 3-choice serial reaction time task. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner. <i>N</i>-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-<i>N</i>-2-pyridinylcyclohexanecarboxamide maleate salt (WAY100635; 0.3 mg/kg, s.c.), a 5-HT<sub>1A</sub> receptor antagonist, did not reverse the suppressing effects of tandospirone on impulsive action. Moreover, a higher dose of WAY100635 (1 mg/kg, s.c.) suppressed impulsive action without tandospirone. Thus the effects of tandospirone on impulsivity might be due to the antagonistic action. Tandospirone could be a therapeutic candidate for impulsivity-related disorders.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 122(2), 84-92, 2013-06-20

    The Japanese Pharmacological Society

References:  41

Codes

  • NII Article ID (NAID)
    10031185400
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13478613
  • NDL Article ID
    024637785
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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