非荷重期間の相違が廃用性筋萎縮後のラットヒラメ筋の回復過程に与える影響  [in Japanese] Influence of Differences in the Duration of Hindlimb Suspension on the Process of Recovery from Disuse Muscle Atrophy of Rat Soleus Muscles  [in Japanese]

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Abstract

〔目的〕非荷重期間の相違が再荷重後の筋肥大に与える影響を検討すること.〔対象〕Wistar系雄ラット28匹の右側ヒラメ筋.〔方法〕7日間の後肢懸垂(H7),懸垂後に再荷重1日(W1),3日(W3),7日(W7)を加えた4群を設定し,同条件の先行研究のコントロール群(C),後肢懸垂14日間の実験群(H14,R1,R3,R7)と,比較・検討した.〔結果〕H7群はC群と有意差がなかったが,H14群では,筋核は有意に減少し,壊死線維は有意に増加した.筋線維横断面積は,非荷重群と比較し,W1群で9%,R1群で5%有意に増加した.〔結語〕非荷重期間が短いほど,再荷重初期の筋線維横断面積増加率が大きかった.<br>

[Purpose] We investigated the influence of differences in the duration of hindlimb suspension (HS) on myofiber hypertrophy. [Subjects] Twenty-eight male Wistar rats were used. [Method] Rats were randomly assigned to groups for 7 days of HS (H7), or HS and 1 day of reloading (W1), 3 days of reloading (W3), or 7 days of reloading (W7). The results were compared with the control, and 14 days of HS and reloading groups (C, H14, R1, R3, R7) of our previous study using the same conditions. [Result] Myonuclear numbers were significantly decreased in the H14 group compared with the C group. Myofiber necrosis was significantly increased in the H14 group compared with the C group. Myofiber cross-sectional area was significantly increased in both the W1 (9%) and R1 groups (5%) compared with the H7 and H14 groups, respectively. [Conclusion] The results suggest that the earlier myofiber was reloaded, the greater the myofiber hypertrophy. <br>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 28(3), 365-370, 2013-06-20

    The Society of Physical Therapy Science

References:  21

Codes

  • NII Article ID (NAID)
    10031185784
  • NII NACSIS-CAT ID (NCID)
    AN10472896
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    13411667
  • NDL Article ID
    024791164
  • NDL Call No.
    Z7-1893
  • Data Source
    CJP  NDL  J-STAGE 
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