Innervation of cerebral vessels and pathogenesis of migraine

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  • 脳血管の神経支配と片頭痛の病態
  • 特別講演 脳血管の神経支配と偏頭痛の病態
  • トクベツ コウエン ノウケッカン ノ シンケイ シハイ ト ヘンズツウ ノ ビョウタイ

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Abstract

Although migraine is not life-threatened disease, its burden in migraineurs is enough severe to affect the productivity in the society around them. Triptans, the most effective agents for the pain in the migraine attacks, have been available since 2000 in Japan. After then, the strategy for migraine treatment has been drastically changed. It has also affected the concept for migraine pathogenesis. Migraine has been attributed to certain abnormality in the cerebral blood vessels per se. However, the trigeminal nerve endings around cerebral or dural vessels are considered to play the key role in the migraine attacks since appearance of the triptans (i.e., trigeminovascular theory). Moreover, recent researches imply many possibilities of the 'migraine generator(s)'in the central nervous system.

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