Electroacupuncture accelerates recovery of muscle atrophy induced by hindlimb suspension in mouse skeletal muscle.

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  • IKEMUNE Sachiko
    Graduate School of Comprehensive Human Science Doctoral Program in Sports Medicine, University of Tsukuba Division of Applied Genome Science and Bioinformatics, Kobe University Graduate School of Medicine
  • OHTA Mika
    Division of Applied Genome Science and Bioinformatics, Kobe University Graduate School of Medicine
  • MACHIDA Masanao
    Graduate School of Comprehensive Human Science Doctoral Program in Health and Sport Sciences, University of Tsukuba
  • TAKEMASA Tohru
    Graduate School of Comprehensive Human Science Doctoral Program in Health and Sport Sciences, University of Tsukuba
  • TAKAOKA Yutaka
    Division of Applied Genome Science and Bioinformatics, Kobe University Graduate School of Medicine
  • MIYAMOTO Toshikazu
    Graduate School of Comprehensive Human Science Doctoral Program in Sports Medicine, University of Tsukuba

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Other Title
  • 後肢懸垂により引き起される筋萎縮の回復過程における鍼通電刺激の効果
  • コウシ ケンスイ ニ ヨリ ヒキオコサレル キン イシュク ノ カイフク カテイ ニ オケル ハリ ツウデン シゲキ ノ コウカ

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Abstract

[Objective]The influence of electroacupuncture (EA) stimulation on physical inactivity is not clear. This study aimed to investigate the effects of EA on the recovery of mouse soleus muscle atrophy induced by hindlimb suspension (HS).<BR>[Methods]We used 8-week-old male ICR mice (n = 20). The mice were divided into 4 groups:the No treatment group (NT, n = 5), HS group (HS, n = 5), Control group (CT, n = 5), and Reloading-with-EA-stimulation group (EA, n = 5). HS mice were suspended for up to 14 days. CT and EA mice were reloaded for an additional 14 days after the HS for 14 days. The HS method used a modified version of an apparatus used in a previous study. EA mice received EA every other day immediately after reloading and were stimulated in the triceps surae muscle at 10 Hz for 30 min with a stainless steel needle. The weight, muscle fiber area size and number of macrophages in the soleus muscle were analyzed.<BR>[Results]The number of skeletal muscle macrophages was increased significantly in EA mice compared with that in CT mice (P < 0.01). The soleus muscle weight and muscle fiber cross-sectional area were decreased in HS mice compared with NT mice (P < 0.01). However, the muscle weight of EA and CT mice increased significantly compared with that of HS mice (P < 0.01). In addition, the muscle weight of EA mice was significantly higher than that of CT mice (P < 0.01), without a significant difference in muscle fiber cross-sectional area between CT and EA mice. <BR>[Conclusion]These results indicate that EA was effective in facilitating the recovery of skeletal muscle atrophy in mice. In addition, resolution of the skeletal muscle atrophy suggested the satellite cell activation by macrophages, because macrophages invaded the skeletal muscle after EA stimulation.

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