Pu-erh Tea Suppresses Diet-Induced Body Fat Accumulation in C57BL/6J Mice by Down-Regulating SREBP-1c and Related Molecules
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- SHIMAMURA Yuko
- Department of Food and Nutritional Sciences, University of Shizuoka
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- YODA Miyuki
- Department of Food and Nutritional Sciences, University of Shizuoka
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- SAKAKIBARA Hiroyuki
- Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University
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- MATSUNAGA Kojiro
- Tealife Company
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- MASUDA Shuichi
- Department of Food and Nutritional Sciences, University of Shizuoka
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抄録
Although pu-erh tea has been shown to suppress hyperlipidemia, it is unclear how it modulates fatty acid synthase expression in mice fed on a high-fat diet. We investigated the effects of a pu-erh tea extract (PTE) on diet-induced body fat accumulation. C57BL/6J mice were fed a control diet, a high-fat diet (HFD), and HFD supplemented with 0.225% or 0.45% PTE for 70 d. Supplementation with PTE reduced the body weight gain, and the abdominal and liver fat accumulation. A significant difference in the triglyceride level were observed between the HFD control and HFD+0.45% PTE groups. A PTE intake tended to decrease sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS) mRNA expression in the liver of the mice. These findings indicate that PTE reduced lipogenesis by down-regulating SREBP-1c and related molecules, leading to the suppression of body fat accumulation.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 77 (7), 1455-1460, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206478869248
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- NII論文ID
- 10031190452
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3sjos1ehtg%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024723551
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- PubMed
- 23832364
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可